Creatine: how to interpret the rate in the blood (creatinemia) and urine (creatinuria)?

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Creatine: how to interpret the rate in the blood (creatinemia) and urine (creatinuria)?

Creatine levels in the blood (creatinemia), what is it?

Creatine, kezako? " Creatine is a natural amino acid found in muscle cellsexplains Dr. François Blanchecotte, Doctor of Pharmacy and President of the Union of Biologists (SDB). It is brought by the animal protein food (meat, fish, eggs ...). "

What is its function ? " Creatine allows the contraction of muscles : this amino acid constitutes (in part) the muscle fibers. It is vital: without it, movement is not allowed! "adds the specialist.

" It is quite rare to dose creatine: this blood test is usually performed to identify a possible muscular pathology. Thus, if the level of creatine in the blood is greater than 15 milligrams per liter, one may suspect muscular dystrophy or myositis, that is, a autoimmune disease that touches the muscles. In children, a high level of creatine in the blood (hypercreatinemia) may identify abnormal growth, with low muscle mass. "

To know : there is no hypocreatinemia since creatine is both stored in muscle cells and produced in the liver, kidneys and pancreas.

Creatinine levels in the blood too high (hypercreatininemia): what can be the causes?

Creatine naturally turns into creatinine after a complex chemical process. " This molecule passes into the urine but it is reabsorbed into the bloodstream at the end of the renal circuit: so a creatinine test is performed at each blood test to take stock of the functioning of the kidneys. explains Dr. Blanchecotte.

The blood test of creatinine is also common in case of chemotherapy (to monitor the renal impairment of treatment) and in dialysis patients.

To know : a "normal" level of creatinine in the blood must be between 60 and 105 μmol (micromoles) per liter.

A elevated serum creatinine concentrations (which corresponds to a level of creatinine too high in the blood) generally reflects a renal damage: " it may reflect a renal failure chronic or acute. This means that the kidneys are no longer doing their job properly "says the specialist.

To know : it is also possible to determine the level of creatinine in the urine (this is known as creatinuria), in which case it must be as low as possible.

Creatinine level in the blood too low (hypocreatininaemia): what can be the causes?

Thehypocréatininémie - which corresponds to a low blood level of creatinine - is more rare. " It is a blood test result that is visible to the naked eyesays Dr. Blanchecotte. The person who suffers from hypocreatinemia is thin, if not undernourished. "

To know : the creatinine measurement (associated with the weight and age of the person) makes it possible to calculate the glomerular filtration rate (GFR): this is the volume of liquid filtered by the kidney per unit of time.

" In a healthy person, GFR is greater than 70 milliliters per minute, develops the specialist. However, this is a more difficult calculation if the person is obese and / or is very old. "

Thanks to Dr. François Blanchecotte, Doctor of Pharmacy and President of Union of Biologists (SDB).

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